To foster translation of this knowledge into clinically useful approaches, this Forum will identify areas in the translation of genomics to neurobiology where a systematic, consensus-based, and collaborative approach to experimental science can help reveal the key neurobiological mechanisms associated with genetic risk for mental illness.ĭigital Ethology: From Individuals to Communities and Back Added to these, several dozen rare mutations of larger-effect sizes offer clues into the origins of psychiatric disease risk, but very little insight into the chain of events that lead to mental illness. Hundreds of risk loci have been identified, most of which are common alleles of very small-effect sizes. This understanding coupled with efforts to amass immense samples and characterize them through GWAS has revealed the genetic architecture of, e.g., schizophrenia, bipolar disorder, depression, and autism.
After many failed attempts to hunt for psychiatric risk genes, we now realize that psychiatric disorders are polygenic. Gordon and Elisabeth Binder, Chairsįor decades, the genetic basis of psychiatric illnesses remained a mystery.
Collectively, this Forum will examine the relationships inherent to stigma and migration-generated diversity.Įxploring and Exploiting Genetic Risk for Psychiatric Disorders Though the origins of prejudice and patterns of social mobility among minority groups have been well studied, understanding is lacking on the empirical patterns of self-reported discrimination and the “integration paradox.” Why does inequality emerge in certain (but not all) second-generation immigrant groups, and how are specific behaviors or traditions selected to sanction a group over others? To address these issues, we need an integrative approach-one grounded in scholarship from the stigma and migration research communities. Majority group reactions and migrant experiences vary widely across and within countries as well as over time. interact with political institutions (e.g., legal status, citizenship, well-being of subsequent generations). Myriad factors underpin migration, and multiple types of conflicts can arise when differences in ethnicity, race, language, religion, etc. Stigma Processes in the Context of Migration-Generated Diversity
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